mRNA差别显示技术在药物靶点上的应用

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a p c t 3 o m s o o ( p I t t d d a a p s w M Ao Ca o C a u t p t r

t a t u n= 1 o m s o 3 a T N= A T i t r o

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X. Wang, Investigator,

R. R. Ruffolo, Jr Vice President and Director, and G.

Z. Feuerstein, Cardiovascular Pharmacology Director, Dlwsion of

Pharmacological Sciences, SmlthKllne Beecham Pharmaceuticals, King of Prussia, PA 19406, USA.

T n o g i t h g i e a 5 1 H o af o t g a e i a g c M t l o g e i c m v w t p c a d s T d e i g g r b t d n o m s e i ag c ( i m s p c a a t p a c i r m l m h i i i t d o p p T d o d e g i e f t u o t m m i i n a p s a w a p n i f d o n m t f p m a d d H a n o t h b d t i g ( k o u s a f t a d e i d s F e n h R p a q r t a p e c r ( h b s u t i d e k g O t s a d t h a s l s h b u s f t d o d f e g w k a u s I t d h m ac l i f p p a t s u p t a m f t d s f e n m a d t S l s i c o o

0 r o mx d t d c o h o t b y x s ( r t ( o y u as o 3 p a (i P a oi c x f u a e i ia ( e p a x p ( p x ( 2 F tn R r t c R ( t p t e t p o g e h m Dm c i r i a t t y t f s x hp c w T i o n T xR f r e i a s ai t m s h n a P oe t t b r t T t R r e a i d i f sd r n g i e u oa d T a p w a A To Ca G e t l b o t 3 B a a l ne o m s a e p e i ac t d o s d g f t R a e ap nr o t m s t b d p p x w w i t y r o x c s o a ar u A o a t c e i a c o u a u e a R t p a a d MessengerRNAexpression u t d M R i t p a p ( t t i x s f t R i t p i o g e t e fe a o u x s p T y l o m o ar ( 2b u n i t c a g r b Tcu p h b io t r u F r m t t b i il c ce 507. o G i me i t a t xr c[ a‘ b c t S m e ar t o ( i a t p[ i yl a a r f t P e t a t 3 a s t i a s b m s t c c T s i e e a l n o t ao a o t p t d m i s c boo p i m e m U t c s t m c b r u io a i t i t p o c r ti a i hc b e T m

t b o t c o a s c l f d f R s f e n a d c o w t m s h b r u h m A t th t n h p t b u i t d o d e g t a t d a l i a r l a o m ( B 1 R an o P m t u d e g h b de r o t t i ( m d i d ( R f a ( a n p P ( 3 T P b t p s a a o t c m a h b u s c f h n g d I p t m d e d m h b a b al n o l o a a i a t t h a f b uii v a i v t s A o s a u ty m f d d i o l i F 1 r

Methodology:s RNA m differential isplay o d

u

2

r

- August

1996

(Vol. 17)

Copyright 01996, Elsevier Science Ltd. All rights reserved. 0165- 6147/96/$15.00

PII: S0165-6147(96)40001-3

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