血管生成素基因多态性是中国北方汉族人群糖尿病神经病的高危因素吗？

Angiogenin gene polymorphism A risk factor for diabetic peripheral neuropathy in the northern Chinese Han

population?

Hongli Wang, Dongsheng Fan, Yingshuang Zhang

Department of Neurology, Peking University Third Hospital, Beijing 100191, China

Abstract:

Angiogenin is associated with the pathogenesis of diabetic peripheral neuropathy. Here, we se-quenced the coding region of the angiogenin gene in genomic DNA from 207 patients with type 2 diabetes mellitus (129 diabetic peripheral

neuropathy patients and 78 diabetic non-neuropathy pa-tients) and 268 healthy controls. All subjects were from the Han population of northern China. No

mutations were found. We then compared the genotype and allele frequencies of the angiogenin synonymous single nucleotide polymorphism rs11701 between the diabetic peripheral neuropathy patients and controls, and between the diabetic neuropathy and non-neuropathy patients, using a case-control design. We

detected no statistically significant genetic associations. Angiogenin may not be associated with genetic susceptibility to diabetic peripheral neuropathy in the Han population of northern China.

Key words： neural regeneration; angiogenin; single nucleotide polymorphism; type 2 diabetes mellitus; diabetic peripheral neuropathy; angiogenesis; diabetic microvascular complications; genetic susceptibility; risk factor; peripheral nerve injury;

grants-supported paper; neuroregeneration;

Acceptance date: 2013-08-11

Cite this article:

Hongli Wang, Dongsheng Fan, Yingshuang Zhang. Angiogenin gene polymorphism A risk factor for diabetic peripheral neuropathy in the northern Chinese Han population?[J]. Neural Regeneration Research, 2013, 8(36): 3434-3440.

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