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Formula:
Purity :Tipifarnib S enantiomer192185-71-0HY-10502A489.40C27H22Cl2N4O>98%
Solubility:DMSO
Mechanisms:
Pathways:Others; Target:Farnesyl Transferase
Biological Activity:
Tipifarnib S enantiomer is the enantiomer of Tipifarnib; Tipifarnib is a potent and specific farnesyltransferaseinhibitor with an IC50 of 0.6 nM.
References:
[1]. Keppner S, et al. Identification and validation of a potent type II inhibitor of inactive polo-like kinase 1.ChemMedChem. 2009 Nov;4(11):1806-9.
[2]. Lange L, et al. Combinatorial inhibition of Plk1 and PKCβ in cancer cells with different p53 status.Oncotarget. 2014 Apr 30;5(8):2263-75.
[3]. Keppner S, et al. Biological impact of freezing Plk1 in its inactive conformation in cancer cells. CellCycle. 2010 Feb 15;9(4):761-73.
Caution: Not fully tested. For research purposes only
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