5-R-Rivaroxaban_865479-71-6_DataSheet_MedChemExpress

Product Data Sheet

Product Name:

CAS No.:

Cat. No.:

MWt:

Formula:

Purity :

5-R-Rivaroxaban865479-71-6HY-76948435.88C19H18ClN3O5S>98%

Solubility:DMSO

Mechanisms:

Pathways:Metabolism/Protease; Target:Factor Xa

gyBiological Activity:

5-R-Rivaroxaban is (R) enantiomer of Rivaroxaban. Rivaroxaban (Xarelto; BAY 59-7939) is a novel,oral, direct Factor Xa (FXa) inhibitor in late-stage development for the prevention and treatment ofthromboembolic disorders.

IC50 value:

Target: Factor Xa

Rivaroxaban (Xarelto; BAY 59-7939) inhibits clot-associated,free FXa activity,and prothrombinaseactivity, in addition, it reduces thrombin generation. Rivaroxaban (Xarelto; BAY 59-7939) is useful forantithrombotic agent.g

References:

[1]. Beyer-Westendorf J, Lützner J, Donath L, Radke OC, Kuhlisch E, Hartmann A, Weiss N, WerthS.

Efficacy and safety of rivaroxaban or fondaparinux thromboprophylaxis in major orthopaedic surgery- findings from the ortho-tep registry.gpgy

J Thromb Haemost. 2012 Aug 6. doi: 10.1111/j.1538-7836.2012.04877.x.

[2]. Helbing T, Bode C, Moser M.

Rivaroxaban in the prevention and treatment of thromboembolic disorders.Hamostaseologie. 2012Aug 1;32(3):195-202.

[3]. Clavé A, Fazilleau F, Dumser D, Lacroix J.

Efficacy of tranexamic acid on blood loss after primary cementless total hip replacement withrivaroxaban thromboprophylaxis: A case-control study in 70 patients.

Orthop Traumatol Surg Res. 2012 Apr 27.

[4]MiHRhdGSttGHCHthNShSPbELidhffLtE [4]. Mani H, Rohde G, Stratmann G, Hesse C, Herth N, Schwers S, Perzborn E, Lindhoff-Last E.Accurate determination of rivaroxaban levels requires different...

Caution: Not fully tested. For research purposes only

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