Avibactam cas#1192500-31-4 Datasheet Medchemexpress

Avibactam cas#1192500-31-4 Datasheet Medchemexpress

Product Data Sheet

Product Name:

CAS No.:

Cat. No.:

MWt:

Formula:

Purity :

Avibactam1192500-31-4HY-14879265.24C7H11N3O6S>98%

Solubility:DMSO

Mechanisms:

Pathways:Anti-infection; Target:Antibacterial

gyBiological Activity:

Avibactam is a non-β-lactam β-lactamase inhibitor antibiotic.

IC50 value:

Target: antibacterial; β-lactamase inhibitor

Avibactam is a novel investigational non-beta-lactam beta-lactamase inhibitor that is being

developed for possible use in combination with ceftaroline in the U.S. Avibactam does not have anyintrinsic antibacterial activity in its own right, but appears to be capable of inhibiting beta-lactamaseenzymes that belong to molecular classes A and C.Avibactam is useful for Antibiotics.

References:

[1]. In vitro activity of avibactam (NXL104) in combination with β-lactams against Gram-negativebacteria, including OXA-48 β-lactamase-producing Klebsiella pneumoniae By Aktas, Z.; Kayacan,

C.; Oncul, O. From International Journal of Antimicrobial Agents (2012)

[2]. Ehmann DE, Jahic H, Ross PL, Gu RF, Hu J, Kern G, Walkup GK, Fisher SL.[]p

Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor.

Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11663-8.

[3]. Akta? Z, Kayacan C, Oncul O.

In vitro activity of avibactam (NXL104) in combination with β-lactams against Gram-negativebacteria, including OXA-48 β-lactamase-producing Klebsiella pneumoniae.

Int J Antimicrob Agents. 2012 Jan;39(1):86-9.

[4]. Castanheira M, Sader HS, Farrell DJ, Mendes RE, Jones RN.

Activity of Ceftaroline-Avibactam Tested against Gram-Negative Organism Populations, in...

Caution: Not fully tested. For research purposes only

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