Avibactam sodium_1192491-61-4_DataSheet_MedChemExpress

Product Data Sheet

Product Name:

CAS No.:

Cat. No.:

MWt:

Formula:

Purity :Avibactam sodium1192491-61-4HY-14879A287.23C7H10N3NaO6S>98%

Solubility:10 mM in water

Mechanisms:

Pathways:Anti-infection; Target:Antibacterial

Biological Activity:

Avibactam sodium(NXL-104) is a non-β-lactam β-lactamase inhibitor antibiotic.

IC50 value:

Target: antibacterial; β-lactamase inhibitor

Avibactam is a novel investigational non-beta-lactam beta-lactamase inhibitor that is being developed forpossible use in combination with ceftaroline in the U.S. Avibactam does not have any intrinsic antibacterialactivity in its own right, but appears to be capable of inhibiting beta-lactamase enzymes that belong tomolecular classes A and C.Avibactam is useful for Antibiotics.

References:

[1]. In vitro activity of avibactam (NXL104) in combination with β-lactams against Gram-negative bacteria,including OXA-48 β-lactamase-producing Klebsiella pneumoniae By Aktas, Z.; Kayacan, C.; Oncul, O. FromInternational Journal of Antimicrobial Agents (2012)

[2]. Ehmann DE, Jahic H, Ross PL, Gu RF, Hu J, Kern G, Walkup GK, Fisher SL.

Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor.

Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11663-8.

[3]. Castanheira M, Sader HS, Farrell DJ, Mendes RE, Jones RN.

Activity of Ceftaroline-Avibactam Tested against Gram-Negative Organism Populations, including StrainsExpressing One or More β-Lactamases and Methicillin-Resistant Staphylococcus aureus Carrying VariousStaphylococcal Cassette Chromosome mec Types.

Antimicrob Agents Chemother. 2012 Sep;56(9):4779-85.

[4]. Livermore DM, Mushtaq S,...

Caution: Not fully tested. For research purposes only

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