Avibactam sodium hydrate__DataSheet_MedChemExpress

Product Data Sheet

Product Name:

CAS No.:

Cat. No.:

MWt:

Formula:

Purity :HY-14879B305.24C7H12N3NaO7S>98%Avibactam sodium hydrate

Solubility:10 mM in H2O

Mechanisms:

Pathways:Anti-infection; Target:Antibacterial

gyBiological Activity:

Avibactam sodium hydrate is a non-β-lactam β-lactamase inhibitor antibiotic.

IC50 value:

Target: antibacterial; β-lactamase inhibitor

Avibactam is a novel investigational non-beta-lactam beta-lactamase inhibitor that is being

developed for possible use in combination with ceftaroline in the U.S. Avibactam does not have anyintrinsic antibacterial activity in its own right, but appears to be capable of inhibiting beta-lactamaseenzymes that belong to molecular classes A and C.Avibactam is useful for Antibiotics.

References:

[1]. Ehmann DE, Jahic H, Ross PL, Gu RF, Hu J, Kern G, Walkup GK, Fisher SL.

Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor.

Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11663-8.

[][2]. Castanheira M, Sader HS, Farrell DJ, Mendes RE, Jones RN.

Activity of Ceftaroline-Avibactam Tested against Gram-Negative Organism Populations, includingStrains Expressing One or More β-Lactamases and Methicillin-Resistant Staphylococcus aureusCarrying Various Staphylococcal Cassette Chromosome mec Types.

Antimicrob Agents Chemother. 2012 Sep;56(9):4779-85.

[3]. Livermore DM, Mushtaq S, Barker K, Hope R, Warner M, Woodford N.

Characterization of β-lactamase and porin mutants of Enterobacteriaceae selected with ceftaroline +avibactam (NXL104).

J Antimicrob Chemother. 2012 Jun;67(6):1354-8.

...

Caution: Not fully tested. For research purposes only

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